​Hui Lab

I am a Professor at the University of California San Diego, where my lab studies immune checkpoint receptors and T cell signaling. We are interested in the molecular mechanisms that control inhibitory signaling in immune cells and in how these pathways shape anti-tumor immunity and cancer immunotherapy.

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My work brings together biophysics, biochemistry, cell biology, and immunology. I am particularly fascinated by how immune receptors communicate across membranes, how their activities are tuned by cis-interactions, and how these mechanisms have evolved across species. I enjoy pursuing these questions at multiple scales, from reconstituted biochemical systems to functional studies in cells and animal models.

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Before coming to UC San Diego, I trained at UCSF and the University of Wisconsin–Madison. Those experiences shaped the way I approach science today: with an emphasis on mechanism, quantitative thinking, and the belief that fundamental discoveries can open unexpected translational opportunities.

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Teaching and mentorship are deeply important to me. At UC San Diego, I teach Structural Biochemistry (BIBC 100) and Metabolic Biochemistry (BIBC 102), and I previously taught Biochemistry of Cell Signaling (BIBC 194). I invest a great deal of thought and energy into creating clear, engaging learning experiences, and I care deeply about helping students and trainees develop confidence, independence, and scientific curiosity. Whether in the classroom or in the lab, I enjoy breaking down complex ideas and helping young scientists grow into creative and rigorous thinkers.

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At the heart of my work is a simple motivation: to understand how immune cells make decisions, and to share that excitement through both discovery and education.