2020 -

Xu X*., Hou B*., Fulzele A., Masubuchi T., Zhao Y., Wu Z., Hu Y., Jiang Y., Ma Y., Wang H., Bennett E., Fu G., Hui E. PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2. Journal of Cell Biology, 2020 [Link] * Equal contributions

2017 - 2019

Zhao Y, Lee CK, Lin CH, Gassen RB, Xu X, Huang Z, Xiao C, Bonorino C, Lu LF, Bui JD, Hui E. PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. Immunity. 2019 Nov 15. PMID: 31757674. [Link]



Sasmal DK, Feng W, Roy S, Leung P, He Y, Cai C, Cao G, Lian H, Qin J, Hui E, Schreiber H, Adams EJ, Huang J. TCR-pMHC bond conformation controls TCR ligand discrimination. Cell Mol Immunol. 2019 Sep 17. doi: 10.1038/s41423-019-0273-6. [Link]


Hui, E. Understanding T cell signaling using membrane reconstitution. Immunol Rev. 2019 Sep;291(1):44-56. doi: 10.1111/imr.12767. [Link]


Hui, E. Immune checkpoint inhibitors. J Cell Biol. 2019 Feb 13. pii: jcb.201810035. [Link]

Zhao, Y., Harrison, D. L., Song, Y., Ji, J., Huang, J., and Hui, E. Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Rep 2018;24:379-90 e376. [Link]

Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD. In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9338-E9345. [Link]


Hui, E., Cheung, J., Zhu, J., Su, X., Taylor, M.J., Wallweber, H., Sasmal, D.K., Huang, J., Kim, J.M., Mellman, I., Vale, R.D. The T-cell costimulatory receptor CD28 is a primary target of PD-1 mediated inhibition. (2017) Science. Mar 31;355(6332):1428-1433 PMID: 28280247 [Link]




Su, X., Diltev, J.A., Hui, E., Xing, W., Banjade, S., Okrut, J., King, D.S., Taunton, J., Rosen, M.K., Vale, R.D. Phase separation of signaling molecules promotes T cell receptor signal transduction (2016) Science. 352(6285):595-9. PMID: 27056144. PMCID: PMC4892427


Chang, C.W., Hui, E., Bai, J., Bruns, D., Chapman, E.R., Jackson, M.B. A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores (2015) J Neurosci 8;35(14):5772-80. PMID: 25855187


Hui, E. & Vale, R.D. In vitro membrane reconstitution of the T cell receptor proximal signaling network (2014) Nat Struct Mol Biol  21(2):133-42. PMCID: PMC3130839


Liu, H., Bai, H., Hui, E., Yang, L., Evans, C., Wang, Z., and Chapman, E.R. Synaptotagmin 7 Functions as a Ca2+ sensor for synaptic vesicle replenishment (2014) Elife 3:e01524. PMCID: PMC3930910


Hui, E.*, Gaffaney, J. D.*, Wang, Z., Johnson, C. P., Evans, C. S., and Chapman, E. R. Mechanism and function of synaptotagmin-mediated membrane apposition (2011) Nat Struct Mol Biol 18, 813-821. *Equal contribution.


Zhang, Z., Hui, E., Chapman, E. R., and Jackson, M. B. Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions (2010) Mol Biol Cell 21, 2821-2831. PMCID: PMC2921110


Zhang, Z., Hui, E., Chapman, E. R., and Jackson, M. B. (2009) Phosphatidylserine regulation of Ca2+ triggered exocytosis and fusion pores in PC12 cells, Mol Biol Cell 20, 5086-5095. PMCID: PMC2793286


Hui, E.*, Johnson, C. P.*, Yao, J.*, Dunning, F. M., and Chapman, E. R. (2009) Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion, Cell 138, 709-721. PMCID: PMC2758036 *Equal contribution.


Shahin, V., Datta, D., Hui, E., Henderson, R. M., Chapman, E. R., and Edwardson, J. M. (2008) Synaptotagmin perturbs the structure of phospholipid bilayers, Biochemistry 47, 2143-2152.


Paddock, B. E., Striegel, A. R., Hui, E., Chapman, E. R., and Reist, N. E. (2008) Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo, J Neurosci 28, 7458-7466. PMCID: PMC2949296


Gaffaney, J. D., Dunning, F. M., Wang, Z., Hui, E., and Chapman, E. R. (2008) Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis, J Biol Chem 283, 31763-31775. PMCID: PMC2581593


Chicka, M. C., Hui, E., Liu, H., and Chapman, E. R. (2008) Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+, Nat Struct Mol Biol 15, 827-835. PMCID: PMC2570314


Hui, E., Bai, J., and Chapman, E. R. (2006) Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I, Biophys J 91, 1767-1777. PMCID: PMC1544279


Czibener, C., Sherer, N. M., Becker, S. M., Pypaert, M., Hui, E., Chapman, E. R., Mothes, W., and Andrews, N. W. (2006) Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes, J Cell Biol 174, 997-1007. PMCID: PMC2064391


Hui, E., Bai, J., Wang, P., Sugimori, M., Llinas, R. R., and Chapman, E. R. (2005) Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis, Proc Natl Acad Sci U S A 102, 5210-5214. PMCID: PMC556003