PUBLICATIONS

2020 -

Wu W*, Zhou Q*, Masubuchi T*, Shi X*, Li H, Xu X, Huang M, Meng L, He X, Zhu H, Gao S, Zhang N, Jing R, Sun J, Wang H, Hui E, Wong CC, Xu C. Multiple Signaling Roles of CD3epsilon and Its Application in CAR-T Cell Therapy. Cell. 2020. PubMed PMID: 32730808. [Link] *Equal contributions

 

Xu X*., Hou B*., Fulzele A., Masubuchi T., Zhao Y., Wu Z., Hu Y., Jiang Y., Ma Y., Wang H., Bennett E., Fu G., Hui E. PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2. Journal of Cell Biology, 2020 [Link] * Equal contributions

2017 - 2019

Zhao Y, Lee CK, Lin CH, Gassen RB, Xu X, Huang Z, Xiao C, Bonorino C, Lu LF, Bui JD, Hui E. PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. Immunity. 2019 Nov 15. PMID: 31757674. [Link]

Comments: 

Highlights: 

Sasmal DK, Feng W, Roy S, Leung P, He Y, Cai C, Cao G, Lian H, Qin J, Hui E, Schreiber H, Adams EJ, Huang J. TCR-pMHC bond conformation controls TCR ligand discrimination. Cell Mol Immunol. 2019 Sep 17. doi: 10.1038/s41423-019-0273-6. [Link]

 

Hui, E. Understanding T cell signaling using membrane reconstitution. Immunol Rev. 2019 Sep;291(1):44-56. doi: 10.1111/imr.12767. [Link]

 

Hui, E. Immune checkpoint inhibitors. J Cell Biol. 2019 Feb 13. pii: jcb.201810035. [Link]

Zhao, Y., Harrison, D. L., Song, Y., Ji, J., Huang, J., and Hui, E. Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Rep 2018;24:379-90 e376. [Link]

Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD. In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9338-E9345. [Link]

 

Hui, E., Cheung, J., Zhu, J., Su, X., Taylor, M.J., Wallweber, H., Sasmal, D.K., Huang, J., Kim, J.M., Mellman, I., Vale, R.D. The T-cell costimulatory receptor CD28 is a primary target of PD-1 mediated inhibition. (2017) Science. Mar 31;355(6332):1428-1433 PMID: 28280247 [Link]

Comments:

PREVIOUS WORK

 

Su, X., Diltev, J.A., Hui, E., Xing, W., Banjade, S., Okrut, J., King, D.S., Taunton, J., Rosen, M.K., Vale, R.D. Phase separation of signaling molecules promotes T cell receptor signal transduction (2016) Science. 352(6285):595-9. PMID: 27056144. PMCID: PMC4892427

 

Chang, C.W., Hui, E., Bai, J., Bruns, D., Chapman, E.R., Jackson, M.B. A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores (2015) J Neurosci 8;35(14):5772-80. PMID: 25855187

 

Hui, E. & Vale, R.D. In vitro membrane reconstitution of the T cell receptor proximal signaling network (2014) Nat Struct Mol Biol  21(2):133-42. PMCID: PMC3130839

 

Liu, H., Bai, H., Hui, E., Yang, L., Evans, C., Wang, Z., and Chapman, E.R. Synaptotagmin 7 Functions as a Ca2+ sensor for synaptic vesicle replenishment (2014) Elife 3:e01524. PMCID: PMC3930910

 

Hui, E.*, Gaffaney, J. D.*, Wang, Z., Johnson, C. P., Evans, C. S., and Chapman, E. R. Mechanism and function of synaptotagmin-mediated membrane apposition (2011) Nat Struct Mol Biol 18, 813-821. *Equal contribution.

 

Zhang, Z., Hui, E., Chapman, E. R., and Jackson, M. B. Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions (2010) Mol Biol Cell 21, 2821-2831. PMCID: PMC2921110

 

Zhang, Z., Hui, E., Chapman, E. R., and Jackson, M. B. (2009) Phosphatidylserine regulation of Ca2+ triggered exocytosis and fusion pores in PC12 cells, Mol Biol Cell 20, 5086-5095. PMCID: PMC2793286

 

Hui, E.*, Johnson, C. P.*, Yao, J.*, Dunning, F. M., and Chapman, E. R. (2009) Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion, Cell 138, 709-721. PMCID: PMC2758036 *Equal contribution.

 

Shahin, V., Datta, D., Hui, E., Henderson, R. M., Chapman, E. R., and Edwardson, J. M. (2008) Synaptotagmin perturbs the structure of phospholipid bilayers, Biochemistry 47, 2143-2152.

 

Paddock, B. E., Striegel, A. R., Hui, E., Chapman, E. R., and Reist, N. E. (2008) Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo, J Neurosci 28, 7458-7466. PMCID: PMC2949296

 

Gaffaney, J. D., Dunning, F. M., Wang, Z., Hui, E., and Chapman, E. R. (2008) Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis, J Biol Chem 283, 31763-31775. PMCID: PMC2581593

 

Chicka, M. C., Hui, E., Liu, H., and Chapman, E. R. (2008) Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+, Nat Struct Mol Biol 15, 827-835. PMCID: PMC2570314

 

Hui, E., Bai, J., and Chapman, E. R. (2006) Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I, Biophys J 91, 1767-1777. PMCID: PMC1544279

 

Czibener, C., Sherer, N. M., Becker, S. M., Pypaert, M., Hui, E., Chapman, E. R., Mothes, W., and Andrews, N. W. (2006) Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes, J Cell Biol 174, 997-1007. PMCID: PMC2064391

 

Hui, E., Bai, J., Wang, P., Sugimori, M., Llinas, R. R., and Chapman, E. R. (2005) Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis, Proc Natl Acad Sci U S A 102, 5210-5214. PMCID: PMC556003